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与运行状态无关的电力系统安全域的理论和方法概述 Feature Article
余贻鑫, 刘艳丽, 秦超, 杨添剀
《工程（英文）》 2020年 第6卷 第7期 页码 754-777 doi: 10.1016/j.eng.2019.11.016
深度学习的几何学解释 Article
雷娜, 安东生, 郭洋, 苏科华, 刘世霞, 罗钟铉, 丘成桐, 顾险峰
《工程（英文）》 2020年 第6卷 第3期 页码 361-374 doi: 10.1016/j.eng.2019.09.010
本文从几何角度来理解深度学习，特别是提出了生成对抗网络（GAN）的最优传输（OT）观点。自然数据集具有内在的模式，该模式可被概括为流形分布原理，即同一类高维数据分布于低维流形附近。从OT的角度来看，生成器用于计算OT映射，而判别器用于计算生成数据分布与真实数据分布之间的Wasserstein距离；两者都可以归结为一个凸优化过程。此外， OT理论揭示了生成器与判别器之间的内在关系是协作的而不是竞争的，并且解释了模式崩溃的根本原因。
关键词： 生成，对抗，深度学习，最优传输，模式崩溃
王琦,董静,吴宏东,王东坡,姚实林,任小娟
《中国工程科学》 2008年 第10卷 第7期 页码 100-103
文章以探索痰湿质的分子机制为目的，在临床流行病学调查的基础上，分别选择6例典型痰湿质和6例典型平和质受试对象，采用 Affymetrix试对痰湿质与平和质组间表达有显著差异的442个基因进行分析，与平和质比较，初步筛选出痰湿质 5个相关基因共 6 个 SNP 位点。固醇运载体 活性等功能，参与糖异生途径、脂肪酸生物合成途径、胆固醇代谢过程、脂肪酸氧化作用、棕色脂肪细胞分化、 细胞葡萄糖调节平衡作用、体温调节作用等生物学过程，痰湿质者在分子水平上具有代谢紊乱的总体特征， 对其分子生物学特征进行了初步探索。
面向视觉概念构建的三维形状空间学习：挑战与研究进展 Perspective
童欣
《信息与电子工程前沿（英文）》 2022年 第23卷 第9期 页码 1290-1297 doi: 10.1631/FITEE.2200318
王英俊, 肖蜜, 夏兆辉, 李培根, 高亮
《工程（英文）》 2023年 第22卷 第3期 页码 94-105 doi: 10.1016/j.eng.2022.07.013
关键词： 人辅助设计 CAD/CAE一体化 等几何分析 结构优化 等几何拓扑优化
代谢组扩展生物学的“旁中心法则”——对理解基因组学-糖组学-代谢组学-表观基因组学互作的意义
Albert Stuart Reece
《工程（英文）》 2023年 第26卷 第7期 页码 16-16 doi: 10.1016/j.eng.2022.07.011
The central dogma of biology holds that the transcription of DNA into RNA and the translation of RNA into proteins forms the primary axis of biological activity [1]. Following major advances in the description of the complex glycan and lipid chains that are added onto these basic building blocks, the glycome and lipidome have recently been added to this doctrine as an exciting new extension named the ‘‘paracentral dogma” [2]. However, it has been pointed out that biological systems can include many layers, which are described in modern omics technology platforms relating to both cell-intrinsic and cell-extrinsic layers of control, including metabolomic, microbiomic, immunological, epigenomic, epitranscriptomic, proteomic and phosphoproteomic layers [3].
It is well known that stem and progenitor cells have a metabolism that is based on glycolysis and glutaminolysis [4]. Although this provides less energy to the cell than oxidative phosphorylation, it suffices for these cells’ needs, since such cells are generally relatively quiescent and normally suppress energy-intensive processes such as genome duplication and transcription. Moreover, it has been shown that the high intracellular lactate levels involved in such states not only inhibits the key gatekeeper enzymes of oxidative phosphorylation (i.e., pyruvate dehydrogenase and carnitine palmitoyl acyltransferase) but also actually covalently modifies them by lactylation in order to maintain this inhibited metabolic–epigenomic state [5]. In addition, intermediate metabolism and nutrients are the source of the very extensive library of post-translational modifications to DNA, RNA, and proteins, as well as supplying cellular energy for many of the required reactions. Hence, the metabolic state locks in and reinforces the epigenomic state, and the metabolome and epigenome thereby play mutually reinforcing roles. This self-reinforcing coordination explains why it is so difficult to generate induced pluripotent cells and is a contributory explanation for why the described protocols typically have such low cellular yields.
These concepts become even more important when it is considered that cancer cells are de-differentiated, similarly rely on glycolysis and glutaminolysis, and are similarly metabolically–epigenomically–genomically synchronized. The disruption of this metabolic system is a key focus of mechanistic cancer research.
These important considerations imply that the descriptive and predictive power of the newly described ‘‘paracentral dogma” of biology may be usefully and meaningfully extended by including the metabolome, along with the genome, transcriptome, proteome, glycome, and lipidome, to describe cell-intrinsic regulation—not only in terms of another omics analytical layer but also as a fully predictive and interactive partner in the symphonic-like multilayer coordination that evidently comprises cellular regulatory layering.
hsa-miR-197在子宫肌瘤中的表达及生物信息学特征分析
徐青,付子毅,吴小莉,皇甫玉爽,凌静
《中国工程科学》 2014年 第16卷 第5期 页码 99-104
关键词： 子宫肌瘤 hsa-miR-197 生物信息学 靶基因
魏益民,徐俊,安道昌,吴永宁,周乃元,潘家荣
《中国工程科学》 2007年 第9卷 第3期 页码 6-10
食品安全学（foodsafetiology）是研究食物对人体健康危害的风险和保障食物无危害风险的学问，是食 品科学的一个分支，也是近３０年来发展起来的一门新兴学科讨论、交流和理解食品安全学的理论基础与技术 体系将有助于促进食品安全学的科学研究、学科建设和人才培养，有助于加强国家食品安全管理和监管能力建 设。在研究大量有关国际组织文件、学术报告、会议文集，以及作者亲自考察、学术研究、自身理解的基础上， 提出了食品安全学的概念，归纳了食品安全学的理论基础和技术体系，探讨了食品安全学的学科构架。
新孢子虫病——分子流行病学及发病机制综述 Review
Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg
《工程（英文）》 2020年 第6卷 第1期 页码 10-19 doi: 10.1016/j.eng.2019.02.010
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2019亚太图学论坛
2019年08月09日
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